1. Denoting mutual opposition in action between structures, agents, diseases, or physiologic processes. Cf.:synergism. 2. The situation in which the combined effect of two or more factors is smaller than the solitary effect of any one of the factors. SYN: mutual resistance. [G. antagonisma, from anti, against, + agonizomai, to fight, fr. agon, a contest]
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an·tag·o·nism an-'tag-ə-.niz-əm n opposition in physiological action:
a) contrariety in the effect of contraction of muscles (as the extensors and flexors of a part)
b) interaction of two or more substances such that the action of any one of them on living cells or tissues is lessened (as by interference with the uptake or by an opposing physiological reaction) compare SYNERGISM
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an·tag·o·nism (an-tagґə-niz″əm) [Gr. antagōnisma struggle] opposition or contrariety between similar things, as between muscles, medicines, or organisms; cf. antibiosis.Medical dictionary. 2011.