cystic fibrosis transmembrane regulator
(CFTR), cystic fibrosis transmembrane conductance regulator a transmembrane protein produced by the CFTR gene, primarily functioning as a cAMP-regulated chloride channel that also regulates other ion channels, and found in cell membranes of the respiratory epithelium, pancreas, salivary glands, sweat glands, intestines, and reproductive tract. Numerous mutations, particularly a deletion causing omission of a phenylalanine residue from the protein, have been associated with cystic fibrosis.
Medical dictionary.
2011.