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ir·re·vers·ible .ir-i-'vər-sə-bəl adj incapable of being reversed: not reversible <an \irreversible medical procedure>: as
a) impossible to make run or take place backward <\irreversible chemical syntheses>
b) of a colloid incapable of undergoing transformation from sol to gel or vice versa
c) of a pathological process of such severity that recovery is impossible <\irreversible brain damage>
ir·re·vers·ibly -'vər-sə-blē adv
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ir·re·ver·si·ble (ir″e-vurґsĭ-bəl) incapable of being reversed.Medical dictionary. 2011.