Generic term for enzymes (EC class 6) catalyzing the joining of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar compound. SEE ALSO: synthetase.
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li·gase (liґgās) [EC 6] a class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. See also synthetase.Medical dictionary. 2011.