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1) the quality or state of being malignant
2 a) exhibition (as by a tumor) of malignant qualities: VIRULENCE
b) a malignant tumor
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ma·lig·nan·cy (mə-ligґnən-se) [L. malignare to act maliciously] 1. a tendency to progress in virulence. 2. the quality of being malignant. 3. a cancer, especially one with the potential to cause death.Medical dictionary. 2011.