Akademik

Fragile site

A term devised in 1969 by Frederick Hecht to denote a heritable point on a chromosome where gaps and breaks tend to occur.

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a nonstaining gap in the chromatin of a metaphase chromosome, usually in both chromatids, and inherited in a mendelian fashion; the chromosome is easily breakable at this site. In cultured human cells, fragile sites are expressed under conditions of folate or thymidine deprivation or in the presence of methotrexate.

Medical dictionary. 2011.