1. Wasting or atrophy of the spinal cord as in tabes dorsalis. 2. Replacement of hemopoietic tissue in the bone marrow by abnormal tissue, usually fibrous tissue or malignant tumors that are most commonly metastatic carcinomas. SYN: panmyelophthisis. [myelo- + G. phthisis, a wasting away]
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my·e·loph·thi·sis (mi″ə-lofґthĭ-sis) [myelo- + phthisis] wasting of the spinal cord. 2. bone marrow suppression secondary to marrow infiltration by tumor with local production of myelosuppressive cytokines.Medical dictionary. 2011.