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A highly conserved DNA sequence of about 180 base pairs near the 3′ end of specific homeotic genes; it encodes a DNA-binding domain that allows the h. proteins to bind to and regulate gene expression in development. SYN: homeodomain.
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ho·meo·box 'hō-mē-ō-.bäks n a short usu. highly conserved DNA sequence in various genes and esp. homeotic genes that encodes a homeodomain
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ho·meo·box (hoґme-o-boks″) any of a class of highly conserved DNA sequences, approximately 180 base pairs long, encoding a protein domain involved in binding to DNA; named for its initial discovery as a Drosophila locus important in homeotic mutation, but it also occurs in many other species, including humans, and is usually found in genes that control development.Medical dictionary. 2011.