Congenital condition manifested by palmar and plantar ulcerating lesions with osteolysis involving distal phalanges of the fingers and toes. Acquired acro-osteolysis has been reported in workers exposed to vinyl chloride. There is an autosomal disorder, Cheney syndrome [MIM*102500], in which this finding is combined with wormian bones, hypoplasia of the mandibular rami, and basilar osteoporosis. SEE ALSO: Cheney syndrome. [acro- + G. osteon, bone, + lysis, loosening]
Medical dictionary. 2011.