Akademik

any one of a class of cytotoxic drug that work by blocking the action of topoisomerase I, an enzyme that promotes the uncoiling of the DNA double helix, which is a necessary preliminary to replication. These drugs include irinotecan (Campto), used for treating advanced colorectal cancer; and topotecan (Hycamtin), for treating advanced ovarian cancer. They are administered by intravenous infusion;

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any of a group of antineoplastic agents that interfere with the arrangement of DNA in cells.