1 make stupid or insensible (stupefied with drink).
2 stun with astonishment (the news was stupefying).
Derivatives:
stupefacient adj. & n. stupefaction n. stupefactive adj. stupefier n. stupefying adj. stupefyingly adv.
Etymology: F stupeacutefier f. L stupefacere f. stupere be amazed
Useful english dictionary. 2012.