The pathologic process that results in the formation and growth of a neoplasm. [neo- + G. plasis, a molding]
- cervical intraepithelial n. dysplastic changes beginning at the squamocolumnar junction in the uterine cervix that may be precursors of squamous cell carcinoma : grade 1, mild dysplasia involving the lower one-third or less of the epithelial thickness; grade 2, moderate dysplasia with one-third to two-thirds involvement; grade 3, severe dysplasia or carcinoma in situ, with two-thirds to full-thickness involvement.
- multiple endocrine n. (MEN) a group of disorders characterized by functioning tumors in more than one endocrine gland. SYN: familial multiple endocrine adenomatosis, multiple endocrine adenomatosis.
- multiple endocrine n. 1 [MIM*131100] syndrome characterized by tumors of the pituitary gland, pancreatic islet cells, and parathyroid glands and may be associated with Zollinger-Ellison syndrome; autosomal dominant inheritance, caused by mutation in the MEN1 gene on chromosome 11q.
- multiple endocrine n. 2 [MIM*171400] syndrome associated with pheochromocytoma, parathyroid adenoma and medullary thyroid carcinoma; autosomal dominant inheritance, caused by mutation in the RET oncogene on chromosome 10q.
- multiple endocrine n. 3 [MIM*162300] syndrome characterized by tumors found in MEN2, tall, thin habitus, prominent lips, and neuromas of the tongue and eyelids; autosomal dominant inheritance, caused by mutation in the RET oncogene on 10q. SYN: multiple endocrine n. 2B.
- prostatic intraepithelial n. (PIN) dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with cell crowding, variation in nuclear size and shape, and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with cell crowding, nucleomegaly and nucleolomegaly, and irregular cell spacing.
- vaginal intraepithelial n. preinvasive squamous cell carcinoma (carcinoma in situ) limited to vaginal epithelium; like vulvar or cervical intraepithelial n., graded histologically on a scale from 1 to 3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papilloma virus infection; may progress to invasive carcinoma.
- vulvar intraepithelial n. preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial n., graded histologically on a scale from 1 to 3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papilloma virus infection; may progress to invasive carcinoma.
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neo·pla·sia .nē-ə-'plā-zh(ē-)ə n
1) the process of tumor formation
2) a tumorous condition of the body
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n.
the formation of abnormal cells. See cervical intraepithelial neoplasia, MENS, prostatic intraepithelial neoplasia. Compare hyperplasia.
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neo·pla·sia (ne″o-plaґzhə) the formation of a neoplasm, i.e., the progressive multiplication of cells under conditions that would not elicit, or would cause cessation of, multiplication of normal cells.Medical dictionary. 2011.